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MSD и ImmunoGen вместе проведут КИ противоопухолевой терапии


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MSD и ImmunoGen договорились о совместном проведении клинических исследований нового препарата для лечения рака яичников, пишет The European Pharmaceutical Review. Согласно достигнутым договоренностям, компании оценят эффективность экспериментального мирветуксимаба (mirvetuximab) разработки ImmunoGen в комбинации с пембролизумабом (pembrolizumab) Merck.

Мирветуксимаб соравтансин (mirvetuximab soravtansine) содержит моноклональные антитела, специфичные к FRα-позитивным опухолевым клеткам, а также DM4 — химиотерапевтический агент майтанзиноид. Препарат был разработан для лечения FRα-позитивного рака яичников.

В настоящее время ImmunoGen проводит клинические исследования мирветуксимаба фазы 1b/2. Ожидается, что КИ подбор пациентов для КИ комбинированной терапии начнется во второй половине 2016 года.

Пембролизумаб был одобрен Администрацией по контролю за продуктами и лекарствами США (FDA) для терапии нерезектабельной меланомы в сентябре 2014 года. Тогда в FDA заявили, что пембролизумаб стал первым зарегистрированным средством, блокирующим белок программируемой смерти клеток – 1 (PD1) и восстанавливающим способность иммунной системы пациента распознавать и уничтожать опухолевые клетки.

 

Источник: ria-ami.ru

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